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"I am always very emphatic in proscribing Direct IV injection of the gas [oxygen-ozone] mixture: Unfortunately charlatans and technicians without medical qualification do this because they either are stupid or because they cannot do major AHT. It has been well defined that a gas injection with a volume above 20ml can produce a deadly embolism. Thus why risk harming the patient? Moreover, it does not matter that it is not ozone, but actually oxygen kills the patients. Indeed the minute volume of ozone is immediately dissolved and disappears because of extreme reactive capacity." (10)
He also points out that in the oft-cited 1983 German survey on the safety of ozone applications, the only adverse side effects were attributed to direct IV injection. Administering ozone through this method is considered medical malpractice in Europe, and has been outlawed there since 1984. (11)
Ozone IV and Saline
First developed by researchers affiliated with the Russian Association of Ozonetherapy in Nisni Novgorod, the intravenous IV method appears to be free of the dangers of embolism. (12)
Using an ozone generator, fill spout and ozone destructor unit, oxygen and ozone is bubbled into a prescribed amount of saline (the Russians use 200 or 400 ml of sterile physiological 0.9 percent sodium chloride solution), the kind usually used in IV drips. The ozonated saline is then infused slowly into the patient through a vein, as would a normal intravenous saline drip.
While Russian studies have found this method to be both safe and effective, 16 similar research has not been done in the West. However, physicians who have used this method have reported good results with minimal adverse reactions. Some possible clinical applications for this ozone delivery method could include treating disease-causing microorganisms in the blood, as well as rheumatic diseases, inflammatory conditions and degenerative diseases like arteriosclerosis, diabetes and cancer.
According to Natalia Bernikova of Medozons, Ltd. [a company formed by the Russian Association of Ozonetherapy and the Russian Federal Nuclear Centre ARZAMAS] (13): “Intravenous infusion of ozonated saline is still procedure No. 1 in Russia, being a priority of the Russian technology of ozone therapy and considered as a better systemic alternative to major autohaemotherapy and rectal insufflations. Nevertheless, the latter methods have been used in Russia as well, depending on the indication.” (14)
However, this method is not without its critics, especially Dr. Bocci. He writes,“Unless very low levels of ozonation are adopted, some formation of hypocloric acid, with time, will cause venous damage, possibly phlebitis” and could “possibly induce intravascular coagulation”. He also dismissed this method more as a placebo than a real treatment. (15)
I also asked Dr. Renate Viebahn her views on this subject, and she replied: "As to the ozonization of saline I am of the same opinion as Prof. Bocci: we have measured the reaction products under different conditions and approaches. The results are not promising: we always got NaOCl [hypochloric acid] which is toxic to blood and blood vessels. So, there is no recommendation to treat saline or another solution containing physiological NaCl solution. I know there are Russian groups treating patients that way but with very, very low ozone concentrations." (16)
Extracorporeal Blood Circulation (EBOO)
EBOO is an experimental procedure developed by Velio Bocci and others in Italy. Its’ goal is to ozonate large amounts of blood in a single session (five liters over a period of 30 to 45 minutes), using a method similar to kidney dialysis. However, Bocci is critical on the use of dialysis filters:
I condemn the use of dialysis filters because they are ineffective and toxic, and unfortunately Russians and other charlatans in Kenya, Malaysia etc. use them. We need only to exchange gas and therefore we can use only appropriate hydrophobic gas exchanger coated with biocompatible compounds to prevent platelet activation. The system operates quite differently from dialysis because blood run outside the ozone-resistant hollow-fiber tubings. (17)
By 2006, it was used on several dozen volunteers, mostly suffering from serious coronary disease. Most received fourteen treatments over a period of several weeks, with periodic follow-up treatments. Improvements were noted in all patients.
Dr. Bocci feels that EBOO can be potentially useful in patients with chronic, inoperable ischemic limbs (where amputation is the only alternative), severe coronary angiostenosis (narrowing of the blood vessels), chronic hepatitis C, acute cardiac ischemia, inoperative metastatic cancer and severe lipodystrophies, which are characterized by abnormalities in fatty tissue (that can be associated with total or partial loss of body fat), abnormalities of carbohydrate and lipid metabolism, severe resistance to insulin and immune system dysfunction.
However, disadvantages include the high costs of a disposable oxygenator and training a highly-qualified technician, possible deterioration of access to veins, and complications associated with the occasional need to insert a catheter into a central vein. (18)
Intraperitoneal (IP) Ozone
Another highly experimental yet promising method is administering oxygen and ozone into the peritoneum, a thin membrane that lines the abdominal and pelvic cavities that covers most abdominal viscera. Russian physicians have been washing out purulent material with ozonized water in treating peritonitis and pleural empyema for years with good results, and Dr. Bocci has explored the possibility of using this method to treat chronic viral hepatitis. (19)
Administering medication through the peritoneum is rare, but not unknown. An 2006 article in The New York Times highlighted how this method can help prolong the lives of ovarian cancer patients and reported that the National Cancer Institute took the unusual step to encourage doctors to adopt this previously little used abdominal treatment. (20)
A new technique to administer intraperitoneal ozone was developed by Dr. Siegfried Schulz and others from various institutes and departments (Veterinary Services and Laboratory Animal Medicine; the Department of Otorhinolaryngology, Head and Neck Surgery; the Department of Pathology; the Institute of Anatomy and Cell Biology and the Department of Pediatrics) at the Philipps-Universität of Marburg, Germany. Dr. Schulz and his colleagues believe that intraperitoneal application can yield great benefits for patients suffering from cancer and severe bacterial diseases like sepsis and enterocolitis. (21)
Topical Applications
Ozonated Water
This method calls for ozone gas to be bubbled through water, and the water is used externally to bathe wounds, burns and slow-healing skin infections. It is also used as a disinfectant by dentists who perform dental surgery. In Russia, physicians are using ozonated water to irrigate body cavities during surgery. In both Russia and Cuba, ozonated water is used to treat a wide variety of intestinal and gynecological problems, including ulcerative colitis, duodenal ulcers, gastritis, diarrhea and vulvovaginitis. Ozonated water can also be used for colonics or enemas.
http://www.oxygenprescription.com/OzoneDelivery.html